OriGene - CXCR5 (NM_032966) cDNA Clone

OriGene Data

Vector:	pCMV6-XL4	Insert Size: 2800	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	GPCR Transmembrane Druggable Genome
Protein Pathways:	Cytokine-cytokine receptor interaction Chemokine signaling pathway

Reference Data

RefSeq: NM_032966.1, NP_116743	RefSeq Size: 2893	RefSeq ORF: 984
Synonyms : BLR1; CD185; MDR15
LocusID: 643	Cytogenetic: 11q23.3
Summary: This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]. Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.

TrueClone Citations:

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2, Jonas S. Jutzi, Ruzhica Bogeska, Gorica Nikoloski, Corina A. Schmid, Thalia S. Seeger, Frank Stegelmann, Sven Schwemmers, Albert Gründer, Jan C. Peeken, Monika Gothwal, Julius Wehrle, Konrad Aumann, Kamar Hamdi, Christine Dierks, Wei Wang, Konstanze Döhner, Joop H. Jansen, and Heike L. Pahl, J. Exp. Med., May 2013; 210: 1003 - 1019. [MAFG]

The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase and Stimulates Its Synthetic Activity, Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E. Syväoja, Barbara van Loon, Ulrich Hübscher, and Francesca M. Pisani, J. Biol. Chem., May 2013; 288: 12742 - 12752. [TIPIN]

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals, Xueliang Gao, Haizhen Wang, Jenny J. Yang, Jing Chen, Jiang Jie, Liangwei Li, Yinwei Zhang, and Zhi-Ren Liu, J. Biol. Chem., May 2013; 288: 15971 - 15979. [PKM2]

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors a- and -mediated transactivation, Yukimasa Takeda and Anton M. Jetten, Nucleic Acids Res., May 2013; 10.1093/nar/gkt447. [Prox1 ]

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia, Hanna L. M. Rajala, Samuli Eldfors, Heikki Kuusanmäki, Arjan J. van Adrichem, Thomas Olson, Sonja Lagström, Emma I. Andersson, Andres Jerez, Michael J. Clemente, Yiyi Yan, Dan Zhang, Andy Awwad, Pekka Ellonen, Olli Kallioniemi, Krister Wennerberg, Kimmo Porkka, Jaroslaw P. Maciejewski, Thomas P. Loughran, Jr, Caroline Heckman, and Satu Mustjoki, Blood, May 2013; 121: 4541 - 4550. [STAT5B]

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites, Isabelle Bally, Sarah Ancelet, Christine Moriscot, Florence Gonnet, Alberto Mantovani, Régis Daniel, Guy Schoehn, Gérard J. Arlaud, and Nicole M. Thielens, PNAS, May 2013; 110: 8650 - 8655. [C1qA]

MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension, Ryan S. Friese, Angelina E. Altshuler, Kuixing Zhang, Jose Pablo Miramontes-Gonzalez, C. Makena Hightower, Martin L. Jirout, Rany M. Salem, Jiaur R. Gayen, Nitish R. Mahapatra, Nilima Biswas, Mo Cale, Sucheta M. Vaingankar, Hyung-Suk Kim, Maïté Courel, Laurent Taupenot, Michael G. Ziegler, Nicholas J. Schork, Michal Pravenec, Sushil K. Mahata, Geert W. Schmid-Schönbein, and Daniel T. O'Connor, Hum. Mol. Genet., May 2013; 10.1093/hmg/ddt213. [HAND1]

Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO), Dirk Winkler, Maria Beconi, Leticia M. Toledo-Sherman, Michael Prime, Andreas Ebneth, Celia Dominguez, and Ignacio Muñoz-Sanjuan, J Biomol Screen, May 2013; 10.1177/1087057113489731. [KMO]

More TrueClone Citations >>

CXCR5 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC207995	Mus musculus chemokine (C-X-C motif) receptor 5 (Cxcr5) as transfection-ready DNA	10 ug	$380	Next day
MR205790	Myc-DDK-tagged ORF clone of Mus musculus chemokine (C-X-C motif) receptor 5 (Cxcr5) as transfection-ready DNA	10 ug	$380	4 weeks
MG205790	GFP-tagged ORF clone of Mus musculus Burkitt lymphoma receptor 1 (Blr1) in a GFP expression vector	10 ug	$420	Next day

CXCR5 Rat Clones

SKU	Description	Amount	Price	Shipping
RN206843	NativeORF clone of Rattus norvegicus chemokine (C-X-C motif) receptor 5 (Cxcr5) as transfection-ready DNA	10 ug	$380	4 weeks
RR206843	Myc-DDK-tagged ORF clone of Rattus norvegicus chemokine (C-X-C motif) receptor 5 (Cxcr5) as transfection-ready DNA	10 ug	$380	4 weeks

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CXCR5 (NM_032966) Human cDNA Clone

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CXCR5 Mouse Clones

CXCR5 Rat Clones

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