OriGene - ACE2 (NM_021804) cDNA Clone

OriGene Data

Vector:	pCMV6-XL4	Insert Size: 3800	Restriction Site:
Sequence Data:	5' Read Nucleotide Sequence 3' Read Nucleotide Sequence
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Secreted Protein Transmembrane Druggable Genome
Protein Pathways:	Renin-angiotensin system

Reference Data

RefSeq: NM_021804.1, NP_068576	RefSeq Size: 3405	RefSeq ORF: 2418
Synonyms : ACEH
LocusID: 59272	Cytogenetic: Xp22
Summary: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008].

TrueClone Citations:

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2, Jonas S. Jutzi, Ruzhica Bogeska, Gorica Nikoloski, Corina A. Schmid, Thalia S. Seeger, Frank Stegelmann, Sven Schwemmers, Albert Gründer, Jan C. Peeken, Monika Gothwal, Julius Wehrle, Konrad Aumann, Kamar Hamdi, Christine Dierks, Wei Wang, Konstanze Döhner, Joop H. Jansen, and Heike L. Pahl, J. Exp. Med., May 2013; 210: 1003 - 1019. [MAFG]

The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase and Stimulates Its Synthetic Activity, Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E. Syväoja, Barbara van Loon, Ulrich Hübscher, and Francesca M. Pisani, J. Biol. Chem., May 2013; 288: 12742 - 12752. [TIPIN]

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals, Xueliang Gao, Haizhen Wang, Jenny J. Yang, Jing Chen, Jiang Jie, Liangwei Li, Yinwei Zhang, and Zhi-Ren Liu, J. Biol. Chem., May 2013; 288: 15971 - 15979. [PKM2]

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors a- and -mediated transactivation, Yukimasa Takeda and Anton M. Jetten, Nucleic Acids Res., May 2013; 10.1093/nar/gkt447. [Prox1 ]

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia, Hanna L. M. Rajala, Samuli Eldfors, Heikki Kuusanmäki, Arjan J. van Adrichem, Thomas Olson, Sonja Lagström, Emma I. Andersson, Andres Jerez, Michael J. Clemente, Yiyi Yan, Dan Zhang, Andy Awwad, Pekka Ellonen, Olli Kallioniemi, Krister Wennerberg, Kimmo Porkka, Jaroslaw P. Maciejewski, Thomas P. Loughran, Jr, Caroline Heckman, and Satu Mustjoki, Blood, May 2013; 121: 4541 - 4550. [STAT5B]

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites, Isabelle Bally, Sarah Ancelet, Christine Moriscot, Florence Gonnet, Alberto Mantovani, Régis Daniel, Guy Schoehn, Gérard J. Arlaud, and Nicole M. Thielens, PNAS, May 2013; 110: 8650 - 8655. [C1qA]

MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension, Ryan S. Friese, Angelina E. Altshuler, Kuixing Zhang, Jose Pablo Miramontes-Gonzalez, C. Makena Hightower, Martin L. Jirout, Rany M. Salem, Jiaur R. Gayen, Nitish R. Mahapatra, Nilima Biswas, Mo Cale, Sucheta M. Vaingankar, Hyung-Suk Kim, Maïté Courel, Laurent Taupenot, Michael G. Ziegler, Nicholas J. Schork, Michal Pravenec, Sushil K. Mahata, Geert W. Schmid-Schönbein, and Daniel T. O'Connor, Hum. Mol. Genet., May 2013; 10.1093/hmg/ddt213. [HAND1]

Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO), Dirk Winkler, Maria Beconi, Leticia M. Toledo-Sherman, Michael Prime, Andreas Ebneth, Celia Dominguez, and Ignacio Muñoz-Sanjuan, J Biomol Screen, May 2013; 10.1177/1087057113489731. [KMO]

More TrueClone Citations >>

ACE2 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC221763	Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 1 as transfection-ready DNA	10 ug	$970	6 weeks
MC221764	Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 2 as transfection-ready DNA	10 ug	$970	6 weeks
MR210755	Myc-DDK-tagged ORF clone of Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 1 as transfection-ready DNA	10 ug	$970	Next day
MR227195	Myc-DDK-tagged ORF clone of Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 2 as transfection-ready DNA	10 ug	$970	6 weeks
MG210755	GFP-tagged ORF clone of Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2) in a GFP expression vector	10 ug	$1070	3 weeks
MG227195	GFP-tagged ORF clone of Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2) transcript variant 2 as transfection-ready DNA	10 ug	$1070	3 weeks

ACE2 Rat Clones

SKU	Description	Amount	Price	Shipping
RN214151	NativeORF clone of Rattus norvegicus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2) as transfection-ready DNA	10 ug	$967	6 weeks
RR214151	Myc-DDK-tagged ORF clone of Rattus norvegicus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2) as transfection-ready DNA	10 ug	$967	6 weeks

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Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

ACE2 (NM_021804) Human cDNA Clone

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ACE2 Mouse Clones

ACE2 Rat Clones

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