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Home TrueClone LATS2 Clone

LATS2 (NM_014572) Human Kinase Deficient Mutant

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC323550 LATS2 (untagged)-Kinase deficient mutant (K697M) of Human LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2) (10ug), NM_014572.1, 10ug $1960 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA315329 Rabbit polyclonal anti-LATS2 antibody, 100ul $325 3 Weeks
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Click here for the corresponding wild type clone.

OriGene Data
Vector:pCMV6-XL5 Insert Size: 4200 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseDruggable Genome
Reference Data
RefSeq: NM_014572.1, NP_055387
RefSeq Size: 4098 RefSeq ORF: 3267
Synonyms : KPM
LocusID: 26524 Cytogenetic: 13q11 Domains: UBA, pkinase, S_TK_X, TyrKc, S_TKc
Summary: This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008].


* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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