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RefSeq: NM_001018064.1,
NP_001018074
LocusID:
4915
Cytogenetic:
9q22.1
Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Transcript Variant: This variant (c) includes the tyrosine kinase catalytic domain and omits an internal coding exon (17), resulting in a slightly shorter isoform (c).
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