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Home TrueClone KLK6 Clone

KLK6 (NM_001012965) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC301735 KLK6 (untagged)-Human kallikrein-related peptidase 6 (KLK6), transcript variant C, NM_001012965.2, 10ug $390 3 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA309722 Rabbit Polyclonal Kallikrein 6 Antibody, 0.1ml $325 3-7 Days
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OriGene Data
Vector: pCMV6 Entry QM Insert Size: Restriction Site: SgfI-MluI
Sequence Data: Fully Sequenced ORF         
OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Secreted ProteinProteaseDruggable Genome
Reference Data
RefSeq Explanation: NM_001012965.2, NP_001012983
RefSeq Size: 1676 RefSeq ORF: 414
Synonyms : Bssp; hK6; Klk7; PRSS18; PRSS9; SP59
LocusID: 5653 Cytogenetic: 19q13.3
Gene Summary: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].

Transcript Variant: This variant (C), also called splice variant 2, differs in the 5' UTR and has multiple coding region differences, compared to variant A. These differences result in predicted translation initiation at a downstream ATG. The resulting isoform (B) has a shorter N-terminus when it is compared to isoform A. This transcript is supported by multiple ESTs, but the predicted ORF has not yet been experimentally confirmed.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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