OriGene - CD53 (NM_000560) cDNA Clone

OriGene Data

Vector:	pCMV6-XL5	Insert Size: 1530	Restriction Site: NotI-NotI
Sequence Data:	5' Read Nucleotide Sequence 3' Read Nucleotide Sequence
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Transmembrane
Protein Pathways:

Reference Data

RefSeq: NM_000560.2, NP_000551	RefSeq Size: 1504	RefSeq ORF: 660
Synonyms : MOX44; TSPAN25
LocusID: 963	Cytogenetic: 1p13	Domains: transmembrane4
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

TrueClone Citations:

Dihydrotestosterone and Bicalutamide Do Not Affect Periostin Expression in Androgen-dependent LNCaP Prostate Cancer Cell Lines, FRANCESCA ARGELLATI, PIER VITALE NUZZO, FRANCESCO RICCI, ROSA MANGERINI, ALESSANDRA RUBAGOTTI, and FRANCESCO BOCCARDO, Anticancer Res, Mar 2013; 33: 815 - 820. [POSTN]

An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart, Eva Tritsch, Youssef Mallat, Florence Lefebvre, Nicolas Diguet, Brigitte Escoubet, Jocelyne Blanc, Leon J. De Windt, Daniele Catalucci, Grégoire Vandecasteele, Zhenlin Li, and Mathias Mericskay, Cardiovasc Res, Mar 2013; 10.1093/cvr/cvt042. [JunD]

CSF1R mutations link POLD and HDLS as a single disease entity, Alexandra M. Nicholson, Matt C. Baker, NiCole A. Finch, Nicola J. Rutherford, Christian Wider, Neill R. Graff-Radford, Peter T. Nelson, H. Brent Clark, Zbigniew K. Wszolek, Dennis W. Dickson, David S. Knopman, and Rosa Rademakers, Neurology, Mar 2013; 80: 1033 - 1040. [CSF1R ]

Induced CYP3A4 Expression in Confluent Huh7 Hepatoma Cells as a Result of Decreased Cell Proliferation and Subsequent Pregnane X Receptor Activation, Louise Sivertsson, Irene Edebert, Margareta Porsmyr Palmertz, Magnus Ingelman-Sundberg, and Etienne P. A. Neve, Mol. Pharmacol., Mar 2013; 83: 659 - 670. [NR1I2 ]

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members, Alexis Verger, Jean-Luc Baert, Kathye Verreman, Frédérique Dewitte, Elisabeth Ferreira, Zoé Lens, Yvan de Launoit, Vincent Villeret, and Didier Monté, Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt199. [MED25]

Centaurin-a1-Ras-Elk-1 Signaling at Mitochondria Mediates ß-Amyloid-Induced Synaptic Dysfunction, Erzsebet M. Szatmari, Ana F. Oliveira, Elizabeth J. Sumner, and Ryohei Yasuda, J. Neurosci., Mar 2013; 33: 5367 - 5374. [APP]

Activation of the Ca2+-sensing receptor increases renal claudin-14 expression and urinary Ca2+ excretion, Henrik Dimke, Prajakta Desai, Jelena Borovac, Alyssa Lau, Wanling Pan, and R. Todd Alexander, Am J Physiol Renal Physiol, Mar 2013; 304: F761 - F769. [Cldn14]

Mechanisms by which the orexigen NPY regulates anorexigenic a-MSH and TRH, Nicole E. Cyr, Anika M. Toorie, Jennifer S. Steger, Matthew M. Sochat, Samantha Hyner, Mario Perello, Ronald Stuart, and Eduardo A. Nillni, Am J Physiol Endocrinol Metab, Mar 2013; 304: E640 - E650. [NYP1R]

Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway, David R. Croucher, Falko Hochgräfe, Luxi Zhang, Ling Liu, Ruth J. Lyons, Danny Rickwood, Carole M. Tactacan, Brigid C. Browne, Naveid Ali, Howard Chan, Robert Shearer, David Gallego-Ortega, Darren N. Saunders, Alexander Swarbrick, and Roger J. Daly, Cancer Res., Mar 2013; 73: 1969 - 1980. [SGK269 ]

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CD53 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC201581	Mus musculus CD53 antigen (Cd53) as transfection-ready DNA	10 ug	$165	Next day
MR202472	Myc-DDK-tagged ORF clone of Mus musculus CD53 antigen (Cd53) as transfection-ready DNA	10 ug	$380	Next day
MG202472	GFP-tagged ORF clone of Mus musculus CD53 antigen (Cd53) in a GFP expression vector	10 ug	$420	3 weeks

CD53 Rat Clones

SKU	Description	Amount	Price	Shipping
RN200615	NativeORF clone of Rattus norvegicus Cd53 molecule (Cd53) as transfection-ready DNA	10 ug	$380	4 weeks
RR200615	Myc-DDK-tagged ORF clone of Rattus norvegicus Cd53 molecule (Cd53) as transfection-ready DNA	10 ug	$380	4 weeks

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CD53 (NM_000560) Human cDNA Clone

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CD53 Mouse Clones

CD53 Rat Clones

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