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Over 1000 citations of OriGene cDNA clones
Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell–Mediated Tumor Killing and Memory Responses Cancer Prevention Research, Jan 2012; 5: 122 - 137. [HSPB1 ]

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells Mol. Cancer Res., Jan 2012; 10: 133 - 142. [SREBF1 ]

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy Cancer Res., Jan 2012; 72: 527 - 536. [AR ]

CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling J. Biol. Chem., Jan 2012; 287: 1198 - 1209. [Cnr2 ]

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JAK3 (NM_000215) Human cDNA Clone

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Cat. No. Ref. ID Description Amount Price Shipping  
SC125449 NM_000215 ORIGENE UNIQUE VARIANT 1 of Homo sapiens Janus kinase 3 (JAK3) as transfection-ready DNA NM_000215.2 10ug $2030 4 weeks Add to Shopping Cart
    
Click here to learn about OriGene’s recombinant JAK3 protein

Also for JAK3 (NM_000215)

OriGene TrueORF Data
Vector:pCMV6-XL4 Insert Size: 4700 Restriction Site:
Sequence Data: 5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Annotation: This TrueClone was found to represent an alternative form of the specific reference to which it is associated. Its Open Reading Frame (ORF) may represent a novel form or alternative splice variant. By virtue of it being a true transcript (cDNA clone not PCR product), it provides a biologically relevant copy of its mRNA template. For more details, please evaluate the sequence information provided on this website or contact our customer care specialists.
OTI Disclaimer: The sequence of an 'OriGene Unique Variant' differs significantly from the associated reference. It represents a novel splice variant from the same gene locus of the reference. Although such variants are true transcripts and present opportunity for discoveries, they are not yet curated by NCBI and should not be used if the exact reference accession sequence is required.
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseDruggable Genome
Protein Pathways: Chemokine signaling pathwayJak-STAT signaling pathwayPrimary immunodeficiency
Reference Data
RefSeq: NM_000215.2, NP_000206
RefSeq Size: 4025 RefSeq ORF: 3375
Synonyms : JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK
LocusID: 3718 Cytogenetic: 19p13.1 Domains: B41, pkinase, SH2, TyrKc, S_TKc
Summary: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq].


Insert Size determined experimentally by digestion of the clone with Not I restriction enzyme

 

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