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Home TrueClone FGFR3 Clone

FGFR3 (NM_000142) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC310101 FGFR3 (untagged)-Human fibroblast growth factor receptor 3 (FGFR3), transcript variant 1 (10ug) NM_000142.2, 10ug $1450 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA313374 Rabbit polyclonal anti-FGFR3 antibody, 100ul $325 In Stock
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OriGene Data
Vector:pCMV6-XL5 Insert Size: Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Annotation: There are 2 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of no amino acids.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: MAPK signaling pathwayEndocytosisRegulation of actin cytoskeletonPathways in cancerBladder cancer
Reference Data
RefSeq: NM_000142.2, NP_000133
RefSeq Size: 4093 RefSeq ORF: 2421
Synonyms : ACH; CD333; CEK2; HSFGFR3EX; JTK4
LocusID: 2261 Cytogenetic: 4p16.3 Domains: pkinase, TyrKc, S_TKc, ig, IGc2, IG
Summary: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009].

Transcript Variant: This variant (1) is the predominant transcript. The resulting protein (isoform 1) has the IIIc-type C-terminal half of the IgIII domain.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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