IGF1 Receptor (IGF1R) Human Gene Knockout Kit (CRISPR)

CAT#: KN214928BN

IGF1R - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: IGF1 Receptor
• Locus ID: 3480
• Components:

  KN214928G1, IGF1 Receptor gRNA vector 1 in pCas-Guide CRISPR vector

  KN214928G2, IGF1 Receptor gRNA vector 2 in pCas-Guide CRISPR vector

  KN214928BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_000875, NM_001291858
• UniProt ID: P08069
• Synonyms: CD221; IGFIR; IGFR; JTK13
• Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]