Mouse Dok1 activation kit by CRISPRa

CAT#: GA201115

Dok1 CRISPRa kit - CRISPR gene activation of mouse docking protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Dok1
• Locus ID: 13448
• Kit Components:

  GA201115G1, Dok1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201115G2, Dok1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201115G3, Dok1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291799, NM_010070
• UniProt ID: P97465
• Synonyms: AW557123; p62DOK
• Summary: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).[UniProtKB/Swiss-Prot Function]