Human CRM1 (XPO1) activation kit by CRISPRa

CAT#: GA105172

XPO1 CRISPRa kit - CRISPR gene activation of human exportin 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: XPO1
• Locus ID: 7514
• Kit Components:

  GA105172G1, CRM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105172G2, CRM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105172G3, CRM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003400
• UniProt ID: O14980
• Synonyms: CRM1; emb; exp1
• Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]