Human FLT3 activation kit by CRISPRa

CAT#: GA101630

FLT3 CRISPRa kit - CRISPR gene activation of human fms related tyrosine kinase 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: FLT3
• Locus ID: 2322
• Kit Components:

  GA101630G1, FLT3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101630G2, FLT3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101630G3, FLT3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004119, NR_130706
• UniProt ID: P36888
• Synonyms: CD135; FLK-2; FLK2; STK1
• Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]