IFNAR1 Rabbit Polyclonal Antibody

CAT#: TA384483

Interferon alpha/beta Receptor 1 Rabbit polyclonal Antibody

Product Images

Western blot analysis of IFNAR1 in K562 lysates using Interferon alpha/beta Receptor 1 antibody.

Specifications

Product Data

• Applications: FC, IP, WB
• Recommended Dilution: WB: 1/500-1/2000
  IP: 1/50
  FC: 1/50
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human IFNAR1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 90,130kDa
• Gene Name: interferon alpha and beta receptor subunit 1
• Database Link:
  Entrez Gene 3454 Human
  UniProt ID P17181
• Background: Swiss-Prot Acc.P17181.Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
• Synonyms: AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC