LRRC8A Rabbit Polyclonal Antibody

CAT#: TA349190

Rabbit Polyclonal Anti-LRRC8A Antibody

Product Images

Western blot analysis of LRRC8A in EL4 cell lysate with LRRC8A antibody at (A) 1 and (B) 2 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LRRC8A antibody was raised against a 15 amino acid peptide near the amino terminus of human LRRC8A.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: LRRC8A antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 89 kDa; Observed: 95 kDa
• Gene Name: leucine-rich repeat containing 8 family member A
• Database Link:
  NP_062540
  Entrez Gene 56262 Human
  UniProt ID Q8IWT6
• Background: The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1,2). LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1). LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3).
• Synonyms: AGM5; LRRC8; SWELL1