ASCIZ (ATMIN) Rabbit Polyclonal Antibody

CAT#: TA349047

Rabbit Polyclonal Anti-ATMIN Antibody

Product Images

Western blot analysis of ATMIN in 293 cell lysate with ATMIN antibody at (A) 1 and (B) 2 ug/mL.

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  Immunocytochemistry of ATMIN in A431 cells with ATMIN antibody at 5 ug/mL.

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  Immunofluorescence of ATMIN in A431 cells with ATMIN antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ATMIN antibody was raised against a 19 amino acid peptide near the amino terminus of human ATMIN.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ATMIN antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 73, 79, 91 kDa; Observed: 72 kDa
• Gene Name: ATM interactor
• Database Link:
  NP_056066
  Entrez Gene 23300 Human
  UniProt ID O43313
• Background: The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1). ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2). It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3).
• Synonyms: HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168