HDAC3 Mouse Monoclonal Antibody [Clone ID: 3G3-H6-H10]

CAT#: TA346962

Mouse Monoclonal HDAC3 Antibody

Specifications

Product Data

• Clone Name: 3G3-H6-H10
• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for HDAC3 antibody: purified recombinant human HDAC3 protein fragments expressed in E.coli.
• Formulation: ascites
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 49 kDa
• Gene Name: histone deacetylase 3
• Database Link:
  NP_003874
  Entrez Gene 15183 MouseEntrez Gene 84578 RatEntrez Gene 8841 Human
  UniProt ID O15379
• Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
• Synonyms: HD3; RPD3; RPD3-2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors