p27 KIP 1 (CDKN1B) Rabbit Polyclonal Antibody

CAT#: TA332381

Rabbit anti-CDKN1B Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CDKN1B antibody.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:200 - 1:500;IF 1:20 - 1:50
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CDKN1B
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 27 kDa
• Gene Name: cyclin-dependent kinase inhibitor 1B
• Database Link:
  NP_004055
  Entrez Gene 12576 MouseEntrez Gene 1027 Human
  UniProt ID P46527
• Background: CDKN1B Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of CDKN1B are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of CDKN1B can be induced by treatment with interleukin 2 or other mitogens; this involves phosphorylation of CDKN1B and its degradation by the ubiquitin-proteasome pathway (1-4).
• Synonyms: CDKN4; KIP1; MEN1B; MEN4; P27KIP1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer