Claudin 4 (CLDN4) Rabbit Polyclonal Antibody

CAT#: TA321324

Anti-CLDN4 Rabbit Polyclonal Antibody

Product Images

Gel: 10+12%SDS-PAGE Lysate: 30 μg Lane: HT29 cells Primary antibody: TA321324 (CLDN4 Antibody) at dilution 1/700 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 30 seconds

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA321324 (CLDN4 Antibody) at dilution 1/35 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA321324 (CLDN4 Antibody) at dilution 1/35, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: HT-29 cells
  IHC: 25-100
  Positive control: Human breast cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 193-209 amino acids of Human claudin 4
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kDa
• Gene Name: claudin 4
• Database Link:
  NP_001296
  Entrez Gene 12740 MouseEntrez Gene 1364 Human
  UniProt ID O14493
• Background: Claudin 4; also known as CLDN4; is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins. This gene encodes an integral membrane protein; which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome; a neurodevelopmental disorder affecting multiple systems.
• Synonyms: CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction