Axin 2 (AXIN2) Rabbit Polyclonal Antibody

CAT#: TA319745

Rabbit Polyclonal AXIN2 Antibody

Product Images

Western blot analysis of AXIN2 in mouse lung lysate with AXIN2 antibody at 1ug/ml.

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  Immunohistochemistry of AXIN2 in mouse lung tissue with AXIN2 antibody at 5ug/ml.

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  Immunohistochemistry of AXIN2 in rat lung tissue with AXIN2 antibody at 5ug/ml.

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  Immunofluorescence of AXIN2 in Rat Lung cells with AXIN2 antibody at 20ug/ml.

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  Immunofluorescence of AXIN2 in mouse lung tissue with AXIN2 antibody at 20ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. The immunogen is located within amino acids 780 - 830 of AXIN2.
• Formulation: AXIN2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: AXIN2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: axin 2
• Database Link:
  AAF22799
  Entrez Gene 8313 Human
  UniProt ID Q9Y2T1
• Background: AXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
• Synonyms: AXIL; ODCRCS