DAP1 (DAP) Rabbit Polyclonal Antibody

CAT#: TA319633

Rabbit Polyclonal DAP Antibody

Product Images

Western blot analysis of DAP in human small intestine tissue lysate with DAP antibody at 1 ug/mL.

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  Immunohistochemistry of DAP in human small intestine tissue with DAP antibody at 5 ug/mL.

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  Immunofluorescence of DAP in human small intestine tissue with DAP antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DAP antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DAP.
• Formulation: DAP Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DAP Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 11 kDa; Observed: 11 kDa
• Gene Name: death-associated protein
• Database Link:
  NP_004385
  Entrez Gene 64322 RatEntrez Gene 223453 MouseEntrez Gene 1611 Human
  UniProt ID P51397
• Background: DAP Antibody: The Death-associated protein (DAP) is a basic proline-rich 15kDa protein that as a positive mediator of programmed cell death that is induced by interferon-gamma (1). DAP is also a direct substrate of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Under rich nutrient conditions, mTOR phosphorylates DAP at Ser3 and Ser51; under starvation conditions, these residues are dephosphorylated and DAP is converted into an active suppressor of autophagy (2).
• Synonyms: MGC99796