Activin Receptor Type IIA (ACVR2A) Rabbit Polyclonal Antibody

CAT#: TA308578

Rabbit Polyclonal antibody to Activin A Receptor type IIA (activin A receptor, type IIA)

Product Images

Sample (30 ug of whole cell lysate). A: Hela. B: Hep G2. 7.5% SDS PAGE. TA308578 diluted at 1:10000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:5000-1:20000
• Reactivities: Human (Predicted: Mouse, Rat, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 267 and 513 of Activin A Receptor type IIA (Uniprot ID#P27037)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58 kDa
• Gene Name: activin A receptor type 2A
• Database Link:
  NP_001607
  Entrez Gene 11480 MouseEntrez Gene 29263 RatEntrez Gene 92 Human
  UniProt ID P27037
• Background: This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq]
• Synonyms: ACTRII; ACVR2
• Note: Seq homology of immunogen across species: Mouse (100%), Rat (100%), Bovine (100%)

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway