GRAP2 Rabbit Polyclonal Antibody

CAT#: TA308365

Rabbit polyclonal antibody to GRAP2 (GRB2-related adaptor protein 2)

Product Images

Sample (30 ug of whole cell lysate). A: JurKat. 10% SDS PAGE. TA308365 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded Colon ca, using GRAP2 (TA308365) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Mouse, Rat, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 174 of GRAP2 (Uniprot ID#O75791)
• Formulation: 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 38 kDa
• Gene Name: GRB2-related adaptor protein 2
• Database Link:
  NP_004801
  Entrez Gene 17444 MouseEntrez Gene 366962 RatEntrez Gene 9402 Human
  UniProt ID O75791
• Background: This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]
• Synonyms: GADS; GRAP-2; GRB2L; GRBLG; GrbX; Grf40; GRID; GRPL; Mona; P38
• Note: Seq homology of immunogen across species: Mouse (90%), Rat (92%), Bovine (90%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: T cell receptor signaling pathway