CACNA1B (alpha-1) Rabbit Polyclonal Antibody

CAT#: AP55389PU-N

CACNA1B (alpha-1) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/500-1/2000.
  Immunohistochemistry: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from N-terminal domain of CACNA1B protein
• Specificity: Reacts with Human 262 kDa CACNA1B protein.
• Formulation: 0.1M Tris, 0.1M Glycine and 2% Sucrose
  State: Purified
  State: Lyophilized powder
  Preservative: None
• Reconstitution Method: Restore in distilled water.
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store lyophilized antibody at -20°C
  Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: calcium voltage-gated channel subunit alpha1 B
• Database Link:
  Entrez Gene 774 Human
  UniProt ID Q00975
• Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1b gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by omega-conotoxin-GVIA (omega-ctx-GVIA) and by omegaagatoxin-IIIA (omega-aga-IIIA). They are however insensitive to dihydropyridines (dhp), and omega-agatoxin-IVA (omegaaga-IVA). Calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
• Synonyms: CACH5, CACNL1A5, Cav2.2, Brain calcium channel III