PSMB10 (C-term) Rabbit Polyclonal Antibody

CAT#: AP53486PU-N

PSMB10 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of PSMB10 Antibody (C-term) in MCF-7 cell line lysates (35ug/lane). This demonstrates the PSMB10 antibody detected the PSMB10 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 213-242 amino acids from the C-terminal region of Human PSMB10
• Specificity: This antibody recognizes Human PSMB10 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: proteasome subunit beta 10
• Database Link:
  Entrez Gene 5699 Human
  UniProt ID P40306
• Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.
• Synonyms: PSMB10, MECL1, Proteasome subunit beta type-10, EC=3.4.25.1, Proteasome subunit beta-2i, Proteasome MECl-1, Macropain subunit MECl-1
• Note: Molecular Weight: 28936 Da

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Proteasome