PITRM1 (Center) Rabbit Polyclonal Antibody

CAT#: AP53312PU-N

PITRM1 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of PITRM1 Antibody (Center) Cat.-NoAP53312PU-Nin MDA-MB231 cell line lysates (35ug/lane). This demonstrates the PITRM1 antibody detected the PITRM1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 497-526 amino acids from the Central region of human PITRM1
• Specificity: This antibody recognizes Human PITRM1 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: pitrilysin metallopeptidase 1
• Database Link:
  Entrez Gene 10531 Human
  UniProt ID Q5JRX3
• Background: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
• Synonyms: Pitrilysin metalloproteinase 1, Metalloprotease 1, MP1, KIAA1104
• Note: Molecular Weight: 117455 Da