Corticotropin Releasing Factor (CRH) (C-term) Rabbit Polyclonal Antibody

CAT#: AP51081PU-N

Corticotropin Releasing Factor (CRH) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of CRH (arrow) usingCorticoliberin Antibody (C-term) Cat.-No AP51081PU-N.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRH gene.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Specificity: This antibody recognizes Human Corticoliberin (C-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: corticotropin releasing hormone
• Database Link:
  Entrez Gene 1392 Human
  UniProt ID P06850
• Background:
  Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
• Synonyms: CRF, CRH, Corticotropin-Releasing Hormone, Corticotropin-Releasing Factor
• Note: Molecular Weight: 21422 Da

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Long-term depression