COP (CARD16) (N-term) Rabbit Polyclonal Antibody

CAT#: AP51022PU-N

COP (CARD16) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

COP1 Antibody (N-term) western blot analysis in CEM, A549 cell line lysates (35ug/lane).This demonstrates the COP1 antibody detected the COP1 protein (arrow).

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  COP1 Antibody (N-term) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, WB
• Recommended Dilution: Western blot: 1/1000.
  Flow Cytometry: 1/10 - 1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COP1
• Specificity: This antibody reacts to COP1.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Chromatography on Protein A, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 22625 Da
• Gene Name: caspase recruitment domain family member 16
• Database Link:
  Entrez Gene 114769 Human
  UniProt ID Q5EG05
• Background: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
• Synonyms: Caspase-1 inhibitor COP, PSEUDO-ICE