Bile salt activated lipase (CEL) (Center) Rabbit Polyclonal Antibody

CAT#: AP50851PU-N

Bile salt activated lipase (CEL) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

CEL Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CEL antibody detected the CEL protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blot: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human CEL
• Specificity: This antibody recognizes Human CEL.
  Other species not tested.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 79322 Da
• Gene Name: carboxyl ester lipase
• Database Link:
  Entrez Gene 1056 Human
  UniProt ID P19835
• Background: The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.
• Synonyms: Bile salt-activated lipase, Carboxyl ester lipase, Sterol esterase, Cholesterol esterase, Pancreatic lysophospholipase, Bucelipase, FAP, BSDL, BSSL, CELL, FAPP, LIPA, CEase, MODY8

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glycerolipid metabolism, Metabolic pathways, Steroid biosynthesis