ABCD1 (Center) Rabbit Polyclonal Antibody

CAT#: AP50017PU-N

ABCD1 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

ABCD1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35 ug/lane).This demonstrates the ABCD1 antibody detected the ABCD1 protein (arrow).

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  ABCD1 antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCD1 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

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  ABCD1 Antibody (Center) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: Western blotting: 1/1000.
  Immunohistochemistry: 1/50 - 1/100.
  Flow Cytomety: 1/50 - 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
• Specificity: This antibody reacts to ABCD1.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: ATP binding cassette subfamily D member 1
• Database Link:
  Entrez Gene 215 Human
  UniProt ID P33897
• Background: ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
• Synonyms: ABC42; adrenoleukodystrophy; ALD; ALDP; AMN
• Note: Molecular Weight: 82937 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: ABC transporters