Neurotensin Receptor 1 (NTSR1) Rabbit Polyclonal Antibody

CAT#: AP31172PU-N

Neurotensin Receptor 1 (NTSR1) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of extracts from MCF7 cells, using NTSR1 antibody. The lane on the right is treated with the synthesized peptide.

• 

  Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NTSR1 antibody was raised against synthetic peptide
• Specificity: This antibody reacts to NTSR1.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: neurotensin receptor 1 (high affinity)
• Database Link:
  Entrez Gene 18216 MouseEntrez Gene 4923 Human
  UniProt ID P30989
• Background: NTR1, a Neurotensin Receptor, activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems. It mediates the functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Neurotensin Receptor 1 expression is enhanced in pancreatic cancer and in chronic pancreatitis (Wang et al, 2000). Two differentially glycosylated forms of the NT1 receptor have been identified in rats, a 54-kD form that is expressed from birth to adulthood, and a 52-kD form only detected at 10 and 15 days postnatal.
• Synonyms: NT-R-1,NTSR1, NTRR, NTR1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction