SFTPC (1-33) Rabbit Polyclonal Antibody

CAT#: AP26404PU-N

SFTPC (1-33) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Frozen Sections: The typical starting working dilution is 1/50.
  Immunohistochemistry on Paraffin Sections: The typical starting working dilution is 1/50.
  Western blot: The typical starting working dilution is 1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant Human pro-SP-C (AA 1-33), GST fusion.
• Specificity: This antibody detects pro-SP-C (AA 1-33).
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  
• Stability: Shelf life: one year from despatch.
• Gene Name: surfactant protein C
• Database Link:
  Entrez Gene 6440 Human
  UniProt ID P11686
• Background:

  There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant.
  SP-C is a 34-35 amino acid peptide, of 4 kD that is proteolytically processed from a 21 kD precursor protein. SP-C is initiated early in the embryogenic period of lung formation, where SP-C transcripts are detected uniformly in epithelial cells lining the primitive airways. During lung development SP-C expression is decreased in cells of the proximal conducting portion of the lung. Ultimately SP-C is expressed selectively in type II epithelial cells in the alveolus of the lung. SP-C is secreted into the airspace where it enhances the spreading and stability of surfactant phospholipids in the alveolus. SP-C plays an important role in the spreading and stabilization of phospholipid films in the alveolus. SP-C is essential for air-breathing in mammals and is therefore largely conserved. Deficiency of SP-C and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS).

• Synonyms: Surfactant protein C, SP-C, SFTP2, SP5