NOTCH1 Rabbit Polyclonal Antibody

CAT#: AP23350PU-N

NOTCH1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot with NOTCH 1 Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1μg/ml.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence at the middle region of human NOTCH1
• Specificity: This antibody detects NOTCH1 (middle). No cross reactivity with other proteins.
• Formulation: State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2 ml of distilled water will yield a concentration of 500 μg/ml
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: notch 1
• Database Link:
  Entrez Gene 4851 Human
  UniProt ID P46531
• Background: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis,1 and the activated Notch 1 and Notch 3 promote ifferentiation of progenitor cells into astroglia.
• Synonyms: Notch 1, hN1, TAN1

Reference Data

• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway
• Protein Pathways: Dorso-ventral axis formation, Notch signaling pathway, Prion diseases