Endothelin B Receptor (EDNRB) (C-term) Rabbit Polyclonal Antibody

CAT#: AP17303PU-N

Endothelin B Receptor (EDNRB) (C-term) rabbit polyclonal antibody

Product Images

Western blot analysis of EDNRB Antibody (C-term) in mouse cerebellum tissue lysates (35 ug/lane). EDNRB (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:50 - 1:100.
  ELISA: 1:1,000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human EDNRB
• Specificity: This antibody detects Endothelin B receptor at C-term.
• Formulation: PBS with 0.29% (W/V) sodium azide
  State: Liquid IG fraction
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: endothelin receptor type B
• Database Link:
  Entrez Gene 13618 MouseEntrez Gene 1910 Human
  UniProt ID P24530
• Background: EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
• Synonyms: ET-BR, ET-B, EDNRB, ETRB, ETB, ETBR, HSCR, WS4A, ABCDS, HSCR2
• Note: Molecular weight: 49644 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction