Dopamine Transporter (SLC6A3) (N-term) Rabbit Polyclonal Antibody

CAT#: AP08320PU-N

Dopamine Transporter (SLC6A3) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Brain, cerebellum: Formalin-Fixed Paraffin Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1 µg/ml.
  Immunohistochemistry on Paraffin Sections: 20 µg/ml.
  Western Blot: 1 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to N-terminal residues of Human DAT (Sodium-dependent Dopamine Transporter).
• Specificity: This antibody recognizes SLC6A3/DAT1 (N-term).
• Formulation: PBS containing 0.01% Sodium Azide as preservative and 50% Glycerol as stabilizer.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: solute carrier family 6 member 3
• Database Link:
  Entrez Gene 6531 Human
  UniProt ID Q01959
• Background: Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. It is a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm.
• Synonyms: Sodium-dependent dopamine transporter, DA transporter, DAT1
• Note: Predicted Molecular Weight: 68 kDa.