Myelin Basic Protein (MBP) Rabbit Polyclonal Antibody

CAT#: AP05363PU-N

Myelin Basic Protein (MBP) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: Western Blot: detects band at 18.5 kDa on reducing SDS-PAGE against rat brain lysate.
  ELISA: 1/100 - 1/400.
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Native Myelin Basic Protein from Human brain
• Specificity: This antibody is specific for myelin basic protein (MBP), an abundant protein component of the myelin membrane and is reported to have a role in its formation and stabilisation.
• Formulation: Phosphate buffered saline containing 0.09% Sodium Azide (NaN3)
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Affinity chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: myelin basic protein
• Database Link:
  Entrez Gene 4155 Human
  UniProt ID P02686
• Background: The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
• Synonyms: MBP