RUNX2 Rabbit Polyclonal Antibody
Other products for "RUNX2"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Western Blot: 1/200-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of RUNX-2 protein. (region surrounding Asp198) |
Formulation | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Predicted Protein Size | ~50.0 kDa |
Gene Name | runt related transcription factor 2 |
Database Link | |
Background | The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2alphaB, CBFA2), RUNX2 (also designated AML-3, PEBP2alphaA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPalphaC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature. |
Synonyms | Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, AML3, AML-3, CBFA1, OSF2, OSF-2, PEBP2A, PEA2-alpha A, PEBP2-alpha A |
Reference Data |
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