KCNK1 Rabbit Polyclonal Antibody

CAT#: AP01494PU-N

KCNK1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of TWIK-1 antibody (Cat.-no.: AP01494PU-N) in extracts from Jurkat cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of TWIK-1 protein. (region surrounding Val322)
• Formulation: Phosphate buffered saline (PBS), pH~7.2 with 0.05% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~38 kDa
• Gene Name: potassium two pore domain channel subfamily K member 1
• Database Link:
  Entrez Gene 3775 Human
  UniProt ID O00180
• Background: K+ channels are divided into three subclasses, reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions, and include TASK, TREK, TRAAK and TWIK. TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney and skeletal muscle. The molecular weight of TWIK-1 in mouse brain is 40 kDa under reducing conditions. TWIK-2 shares low sequence homology with other mammalian family group members, and only 34% homology with TWIK-1. Human TWIK-2 is expressed in pancreas, placenta and heart, while mouse TWIK-2 is expressed in liver. TWIK-2 is inhibited by intracellular, but not extracellular, acidification.
• Synonyms: KCNK1, HOHO1, KCNO1, TWIK1, Potassium channel subfamily K member 1, Potassium channel KCNO1