Cd5 Mouse Monoclonal Antibody [Clone ID: HIS47]

CAT#: AM39067SU-N

Cd5 mouse monoclonal antibody, clone HIS47, Supernatant

Specifications

Product Data

• Clone Name: HIS47
• Applications: IF, IHC
• Recommended Dilution: Flow cytometry.
  Immunofluorescence.
  Immunohistochemistry on frozen sections.
• Reactivities: Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: The antibody recognizes peripheral T lymphocytes and thymocytes (CD5).
  In rats, a CD5+ subset of B lymphocytes has not beem characterized.
• Formulation: State: Supernatant
  State: Liquid cell culture supernatant containing 0.09% sodium azide
• Conjugation: Unconjugated
• Storage: Store undiluted a 2-8°C.
• Gene Name: Cd5 molecule
• Database Link:
  Entrez Gene 54236 Rat
  UniProt ID P51882
• Background: CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, (human) subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor.
  CD72 is the major ligand for CD5.
• Synonyms: CD5, LEU1