PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: 7C9]

CAT#: AM33412PU-N

PD1 (PDCD1) mouse monoclonal antibody, clone 7C9, Aff - Purified

Product Images

Western blot analysis showing 1 ug/well of recombinant Human PD-1 detected with 1 ug/ml of CD279 / PD1 Antibody (Clone 7C9).

Specifications

Product Data

• Clone Name: 7C9
• Applications: ELISA, WB
• Recommended Dilution: Indirect ELISA.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: 40kDa recombinant Human Programmed Cell Death-1 (PD-1).
• Specificity: Reactive with recombinant Human Programmed Cell Death-1 (PD-1).
  Reactivity with natural PD-1 has not been evaluated.
• Formulation: 0.01M PBS, pH 7.2 without preservatives
  State: Aff - Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: programmed cell death 1
• Database Link:
  Entrez Gene 5133 Human
  UniProt ID Q15116
• Background: Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. The protein is expressed on T cells, B cells and macrophages. When PD-1 is joined with its ligand (CD274 or B7-H1), the immune cell’s activation and effector function are attenuated. Research suggested that PD1 pathway is mainly involved with attenuation at periphery sites while the B7/CTLA-4 pathway is primarily involved with the attenuation of the activation of immune cells in secondary lymphoid organs. PD-1 pathway is implicated with cancer’s immune-evasion, autoimmunity, and Listeria monocytogenes infection.
• Synonyms: Protein PD-1, hPD-1, PDCD1