IL27 Mouse Monoclonal Antibody [Clone ID: B-G49]

CAT#: AM31269AF-N

IL27 mouse monoclonal antibody, clone B-G49, Azide Free

Product Images

The graph on the left represents activated dendritic cells marked with B-G49 and the graph on the right shows B-G49 with non-activated dendritic cells. In the two cases, the dotted line represents the IgG2a isotype control (B-Z2).

Specifications

Product Data

• Clone Name: B-G49
• Applications: FC
• Recommended Dilution: Flow Cytometry on Dendritic cells.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant Human IL-27.
• Specificity: Recognizes both natural and recombinant Human IL-27
• Formulation: Phosphate-buffered saline without Carrier and preservatives.
  This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins.
  State: Azide Free
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 27
• Database Link:
  Entrez Gene 246778 Human
  UniProt ID Q8NEV9
• Background: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.
• Synonyms: IL-27 subunit alpha, IL27-A, p28, IL30, IL-30, Interleukin-30

Reference Data

• Protein Families: Druggable Genome, Transmembrane