DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: UW60.1]
CAT#: AM26379PU-N
DC SIGN (CD209) mouse monoclonal antibody, clone UW60.1, Aff - Purified
Conjugation: APC
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Specifications
Product Data | |
Clone Name | UW60.1 |
Applications | FC, IF |
Recommended Dilution | Flow Cytometry. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | CD209-His-tagged fusion protein |
Specificity | The mouse monoclonal antibody UW60.1 recognizes CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages. |
Formulation | PBS, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide |
Concentration | lot specific |
Purification | Protein-A affinity chromatograpy ( > 95% by SDS-PAGE) |
Conjugation | Unconjugated |
Storage | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | CD209 molecule |
Database Link | |
Background | CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3). |
Synonyms | DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker |
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