c Abl (ABL1) Mouse Monoclonal Antibody [Clone ID: 7B11D6]

CAT#: AM06256SU-N

c Abl (ABL1) mouse monoclonal antibody, clone 7B11D6, Ascites

Product Images

Western blot analysis using ABL1 antibody Cat.-No AM06256SU-N against truncated GST-ABL1 recombinant protein (1).

Specifications

Product Data

• Clone Name: 7B11D6
• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.
• Specificity: Recognizes ABL1
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: ABL proto-oncogene 1, non-receptor tyrosine kinase
• Database Link:
  Entrez Gene 25 Human
  UniProt ID P00519
• Background: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
• Synonyms: c-ABL, p150, JTK7, bcr/abl