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Home Antibody All anti-ZBP1 antibodies

Anti-ZBP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306502
  • Rabbit Polyclonal ZBP1 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenZBP1 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human ZBP1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Z-DNA binding protein 1 (ZBP1), transcript variant 2
Alternative NameC20orf183; DAI; DLM-1; DLM1
Database LinkNP_001153889
Entrez Gene 81030 Human
Entrez Gene 58203 Mouse
Entrez Gene 171091 Rat
FunctionZ-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Za domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
Related Pathway Cytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ZBP1 in mouse small intestine tissue lysate with ZBP1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of ZBP1 in human small intestine tissue with ZBP1 antibody at 2.5 ug/ml.

 

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