Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1
Synonyms:
SRK; STCD; STD; TZK; ZAP-70
Immunogen
A synthetic peptide corresponding to residues in human ZAP-70 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
ZAP-70, a Syk-family protein tyrosine kinase, plays a critical role in mediating T cell signal transduction in response to T cell antigen receptor (TCR) activation (1). Its involvement in pre-TCR and TCR signaling affects the adaptive immune response and thymocyte development (2). TCR-mediated activation of the Src-family kinases, Lck and Fyn, results in tyrosine phosphorylation of the TCR zeta and CD3 chains. These domains serve as targets for binding of ZAP-70 via its tandem SH2 domains. This binding correlates with the recruitment of ZAP-70, a critical event in T cell activation (3). Following TCR engagement, ZAP-70 is phosphorylated by several tyrosine residues in the activation loop of the catalytic domain (2). Phosphorylation of Tyr315 and Tyr319 is required for full activation and increased signal propagation of downstream target molecules by ZAP-70 (4).
Related Pathway
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