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Anti-XRCC5 Antibody EPR3468


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307065 Rabbit monoclonal antibody against Ku80 (clone EPR3468 ) 100ul $325 In Stock
LC412062 XRCC5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Ku80 was used as an immunogen.
Clone NameEPR3468 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:50; IHC-P: 1:250 - 1:500; ICC/IF: 1:500 - 1:1000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (XRCC5)
Alternative NameKARP-1; KARP1; KU80; Ku86; KUB2; NFIV
Database LinkNP_066964
Entrez Gene 7520 Human
FunctionThe Ku antigen is a DNA-associated nuclear protein originally recognized by the sera of patients with autoimmune diseases (1). It plays a key role in multiple nuclear processes, such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination (2). The Ku protein is composed of 70 and 82 kDa subunits (Ku70 and Ku80, respectively) and contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway (3). When bound to DNA, the Ku 70/80 heterodimer enhances the kinase activity of the catalytic subunit of the DNA-dependent protein kinase, DNA-PKcs (4).
Related PathwayStem cell - PluripotencyDruggable Genome Non-homologous end-joining

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Ku80 antibody [EPR3468]; All lanes : Anti-Ku80 antibody [EPR3468] at 1/50000 dilution.Lane 1 : A549 cell lysate .Lane 2 : HeLa cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 83 kDa.Observed band size : 83 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ku80 antibody [EPR3468]; Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue using 1/100 TA307065.
Immunocytochemistry/ Immunofluorescence - Ku80 antibody [EPR3468]; Immunofluorescence analysis of HeLa cells with 1/500 TA307065.


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