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Home Antibody All anti-XIAP antibodies

Anti-XIAP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306170
  • Rabbit Polyclonal XIAP Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC420092) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for XIAP (NM_001167)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenXIAP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens X-linked inhibitor of apoptosis (XIAP), transcript variant 1
Alternative NameAPI3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2
Database LinkNP_001158
FunctionApoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The X-chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, and –9 (2,3). Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation; conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation (4). Two negative regulators, termed XAF-1 (5) and Smac (6), can bind and inhibit XIAP activity.
Related Pathway
Apoptosis
Focal Adhesion

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WB Image
Western blot analysis of XIAP in human kidney lysate with XIAP antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/ml, respectively.
IHC Image
Immunohistochemical staining of human kidney tissue using XIAP antibody at 2 ug/ml.

 

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