Search:     All Products Assays Human cDNA clone, untagged Human cDNA clone, tagged RNAi 3'-UTR Clone Human Primer Mouse cDNA clone, untagged Mouse cDNA clone, tagged Rat ORF clone, untagged Rat ORF clone, tagged Virus ORF clone, tagged Mouse Primer qPCR Standard Proteins Mass Spec Standard Antibodies Lysate MicroRNA Expression Plasmids MicroRNA primer pairs MicroRNA template standards Other Products

 

Antibody

UltraMAB IHC Antibodies

TrueMAB Primary Antibodies

Anti-tag Antibodies

ELISA Antibodies

Luminex Antibodies

Secondary Antibodies

Antibody Accessories

Antibody Service

 

Related Products

 

Useful Links

FAQs

Anti-XBP1 Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IF(1)

OriGene Data

Immunogen	XBP-1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human XBP-1.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration	1ug/ul
Guaranteed Application *	WB, IF	Suggested Dilutions	ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml
Buffer	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens X-box binding protein 1 (XBP1), transcript variant 2
Alternative Name	TREB5; XBP-1; XBP2
Database Link	NP_001073007
Function	X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of X-box binding protein 1 (XBP1), transcript variant 2 • Transient overexpression lysate of X-box binding protein 1 (XBP1), transcript variant 2 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • XBP1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • XBP1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Xbp1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • XBP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Xbp1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens X-box binding protein 1 (XBP1), transcript variant 2 as transfection-ready DNA • Lenti ORF clone of Human X-box binding protein 1 (XBP1), transcript variant 2, mGFP tagged • GFP-tagged ORF clone of Homo sapiens X-box binding protein 1 (XBP1), transcript variant 2 as transfection-ready DNA • Lenti ORF clone of Human X-box binding protein 1 (XBP1), transcript variant 2 , Myc-DDK-tagged Related cDNA Clones • Homo sapiens X-box binding protein 1 (XBP1), transcript variant 2 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)