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Home Antibody All anti-XBP1 antibodies

Anti-XBP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306288
  • Rabbit Polyclonal XBP-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC425888) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for XBP1 (NM_001079539)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenXBP-1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human XBP-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens X-box binding protein 1 (XBP1), transcript variant 2
Alternative NameTREB5; XBP-1; XBP2
Database LinkNP_001073007
Entrez Gene 7494 Human
Entrez Gene 22433 Mouse
Entrez Gene 289754 Rat
FunctionX box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of XBP-1 in PC-3 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
IF Image
Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 2 ug/mL.

 

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