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Home Antibody All anti-XBP1 antibodies

Anti-XBP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302701
  • Goat Polyclonal Antibody against XBP1 / TREB5
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401569) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

Immunogen Peptide with sequence C-NHSWEDTFANELFPQ, from the internal region of the protein sequence according to NP_001073007.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat, Dog Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:4,000. WB: 1-3µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Reference Data

Target NameHomo sapiens X-box binding protein 1 (XBP1), transcript variant 1
Alternative NameTREB5; XBP-1; XBP2
Database LinkNP_005071
FunctionThis gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq].
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
TA302701 (1µg/ml) staining of nuclear HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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