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Anti-WT1 Antibody 6F-H2
|Human recombinant WT1 protein (residues 1-181). [Swiss-Prot# P19544]|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 2 ug/ml
|Tris-glycine, 150mM NaCl and 0.05% sodium azide|
|IgG purified (Protein A or G Sepharose)
|Homo sapiens Wilms tumor 1 (WT1), transcript variant D|
|AWT1; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; WT33|
|Wilms?tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and, like retinoblastoma, is observed in both sporadic and inherited forms. The Wilms?tumor locus has been mapped at chromosome 11p13 as a tumor suppressor gene which encodes a DNA binding protein with four zinc fingers and a glutamine-proline rich amino terminus. The Wilms?tumor protein binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators. However, in contrast to Egr transcription factors, WT1 behaves as a transcriptional repressor in transient transfection assays with synthetic promotor constructs.|
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Western Blot- Wilms Tumor 1 Antibody (6F-H2) detects WT1 in 293 cell lysate
Immunohistochemistry- IHC analysis of Wilms Tumor 1 in human renal cancer using DAB with hematoxylin counterstain.