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Home Antibody All anti-WRN antibodies

Anti-WRN Antibody EPR6392

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310944
  • Rabbit Monoclonal antibody against WRN
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human WRN was used as an immunogen.
Clone NameEPR6392 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens Werner syndrome, RecQ helicase-like (WRN)
Alternative NameRECQ3; RECQL2; RECQL3
Database LinkNP_000544
FunctionWRN is a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, WRN may be involved in the repair of double strand DNA breaks. Defects in this protein are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging (1).
Related Pathway

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WB Image
Western blot - Anti-Werner's syndrome helicase WRN antibody [EPR6392]; All lanes : Anti-Werner's syndrome helicase WRN antibody [EPR6392] at 1/1000 dilution.Lane 1 : MOLT4 cell lysates.Lane 2 : K562 cell lysates.Lane 3 : A431 cell lysates.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 162 kDa.

 

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