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Anti-WRN Antibody EPR6392
|A synthetic peptide corresponding to residues near the C-terminus of human WRN was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens Werner syndrome, RecQ helicase-like (WRN)|
|RECQ3; RECQL2; RECQL3|
|WRN is a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, WRN may be involved in the repair of double strand DNA breaks. Defects in this protein are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging (1). |
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Western blot - Anti-Werner's syndrome helicase WRN antibody [EPR6392]; All lanes : Anti-Werner's syndrome helicase WRN antibody [EPR6392] at 1/1000 dilution.Lane 1 : MOLT4 cell lysates.Lane 2 : K562 cell lysates.Lane 3 : A431 cell lysates.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 162 kDa.